Breast Cancer

Description:

According to the American Cancer Society, more than 200,000 women will be diagnosed with invasive breast cancer this year. While breast cancer primarily strikes women, men can be affected as well.

In women, approximately 90 percent of breast cancer starts in the mammary ducts of the breast while 10 percent originates in the lobules, the glands that make breast milk.

>>> What is Breast Cancer?
>>> Breast Cancer Facts
>>> Breast Cancer Statistics

Noninvasive breast cancer / Ductal carcinoma in-situ
Noninvasive breast cancer, ductal carcinoma in-situ, is used to describe breast cancer in its early stages before it has spread outside the duct into the surrounding tissue or to other organs of the body.  In this stage, the cancer remains where it started, in the mammary ducts, and has not spread. Noninvasive cancer increases a woman's risk of developing invasive breast cancer.

Invasive breast cancer
The two most common types of invasive breast cancer are infiltrating ductal carcinoma (IDC) and infiltrating lobular carcinoma (ILC).

IDC is the most common type of invasive breast cancer, accounting for 90 percent of all cases. IDC begins in the milk ducts and invades the tissues of the breast by breaking through the walls of the milk duct. Once in the breast's fatty tissues, IDC can spread to the armpit lymph nodes or to other organs of the body, namely the bones, lungs or liver.

ILC accounts for nearly 10 percent of all invasive breast cancers. ILC starts in the lobules (milk glands) and invades the tissues of the breast by breaking through the walls of the milk glands.  ILC can also spread to the armpit lymph nodes and to other organs of the body.

Symptoms:
  • New lump in the breast
  • Discharge from the nipple
Treatment Options:

Typically, breast cancer is treated with a combination of surgery, chemotherapy and/or hormonal therapies.  In some cases, radiation therapy is also used.

Currently, RMCC has approximately 15 clinical research trials in progress for the treatment of breast cancer.

Recently, RMCC initiated a breast cancer research study for partial breast accelerated intensity modulated radiation therapy (IMRT).  This investigational therapy, which is completed in one week, could potentially substitute for a five to six week treatment of the entire breast.

>>> More Information about Breast Cancer Surgery (Lumpectomy/Mastectomy)
>>> More Information about Chemotherapy
>>> More Information about Hormonal Therapies


Risk Factors:
  • Family history of breast cancer
  • Receiving hormone replacement therapy over an extended period of time
  • Obesity
  • Excessive alcohol use
Prevention:
  • A yearly mammogram and breast exam for all women 40 and older

>>> More Information about Cancer Risk Factors


Online resources:

The American Cancer Society: www.cancer.org
The Susan B. Komen Foundation: www.komen.org
National Cancer Institute: www.nci.nih.gov

Clinical Trials:
NIH Cognition trial
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NSABP B-42
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USON 08200
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USON 08180
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USON 05074
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CTSU/IBCSG 24-02(SOFT)
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CTSU/CALGB 40101
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JMA.17R
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NSABP B-39
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ECOG PACCT-1
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CTSU/SWOG S0307
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USON 06185
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MCCRC PACS 08-0610
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USON 07119
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CTSU/NCCTG N063D
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USON 08223
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NSABP B-37
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USON 06166
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NCCTG N04CA
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NCCTG N0733
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USON 07142
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NSABP B-43
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USON 08007
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USON 08217
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NSABP B-41
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USON 08215
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USON 09132/RTOG/NSABP B-43
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NSABP FRP B-44-I
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NSABP B-40
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USON 07132
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2009-APBI
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