Evolvement in Breast Cancer Treatment
Radiation Therapy for Breast Cancer
External Radiation Therapy
Radiation is delivered to the exact area of the body where the cancer is (or was) located using a linear accelerator. Advanced technologies make it possible to treat the affected area with little impact on the surrounding healthy tissue. Treatments are usually 5 days a week for 4 to 6 weeks at one of the RMBS locations. This is the most common type of radiation therapy used for breast cancer.
High Dose Rate (HDR) Brachytherapy
An applicator is placed inside the breast, pointed at the lumpectomy site. Over the course of a few days, radioactive seeds (or pellets) are placed in the applicator tubes, left for a short period of time, and then removed. This is repeated several times throughout the treatment period.
Hormone Therapy for Breast Cancer
If lab tests show that the tumor in your breast has hormone receptors, meaning that it is fueled by natural hormones (estrogen and progesterone), then hormone therapy may be an option. Hormone therapy, also sometimes called anti-hormone treatment, keeps cancer cells from getting or using the natural hormones they need to grow.
This drug can prevent the original breast cancer from returning and also helps prevent the development of new cancers in the other breast. As treatment for metastatic breast cancer, tamoxifen slows or stops the growth of cancer cells that are in the body. It’s a pill that you take every day for five years. In general, the side effects of tamoxifen are similar to some of the symptoms of menopause. The most common are hot flashes and vaginal discharge. Others are irregular menstrual periods, thinning bones, headaches, fatigue, nausea, vomiting, vaginal dryness or itching, irritation of the skin around the vagina, and skin rash. Serious side effects are rare, but they include blood clots, strokes, uterine cancer, and cataracts. You may want to read the NCI fact sheet on Tamoxifen.
This type of drug can prevent the ovaries from making estrogen. It may be given by injection under the skin in the stomach area. Side effects include hot flashes, headaches, weight gain, thinning bones, and bone pain. Examples are leuprolide and goserelin.
Surgeries to Remove Your Ovaries
Until you go through menopause, your ovaries are your body’s main source of estrogen. When the surgeon removes your ovaries, this source of estrogen is also removed. (A woman who has gone through menopause wouldn’t benefit from this kind of surgery because her ovaries produce much less estrogen.) When the ovaries are removed, menopause occurs right away. The side effects are often more severe than those caused by natural menopause. Your health care team can suggest ways to cope with these side effects.
This type of drug prevents the body from making a form of estrogen (estradiol). Common side effects include hot flashes, nausea, vomiting, and painful bones or joints. Serious side effects include thinning bones and an increase in cholesterol. Examples of aromatase inhibitors include anastrozole, exemestane, and letrozole.
Hormone therapy is given for at least five years. Therefore, if you have gone through menopause, you can expect to receive tamoxifen for 2 to 5 years. If tamoxifen is given for less than five years, then an aromatase inhibitor often is given to complete the five years. Some women have hormone therapy for more than five years. See above for more information about tamoxifen and its possible side effects.
Chemotherapy for Breast Cancer
Targeted Therapy for Breast Cancer
Targeted Therapy for HER2-Positive Breast Cancer
If your cancer has tested positive for a protein called human epidermal growth factor receptor 2 (HER2), it is likely that your breast cancer will grow and spread more aggressively. To target this type of breast cancer, a variety of drugs have been developed, which include:
- Nerlynx: Nerlynx (chemical name: neratinib) is an irreversible pan-HER inhibitor. Nerlynx works against HER2-positive breast cancer by blocking the cancer cells’ ability to receive growth signals.
- Herceptin: Herceptin (chemical name: trastuzumab) works against HER2-positive breast cancers by blocking the ability of the cancer cells to receive chemical signals that tell the cells to grow.
- Perjeta: Like Herceptin, Perjeta (chemical name: pertuzumab) works against HER2-positive breast cancers by blocking the cancer cells’ ability to receive growth signals.
- Kadcyla: Kadcyla (chemical name: T-DM1 or ado-trastuzumab emtansine) is a combination of Herceptin and the chemotherapy medicine emtansine. Kadcyla was designed to deliver emtansine to cancer cells in a targeted way by attaching emtansine to Herceptin. Herceptin then carries emtansine to the HER2-positive cancer cells.
- Tykerb: Tykerb (chemical name: lapatinib) works against HER2-positive breast cancers by blocking certain proteins that can cause uncontrolled cell growth.
Targeted Therapy for Hormone Receptor-Positive Breast Cancer
If your breast cancer is hormone receptor-positive, your treatment will typically begin with hormone therapy. To help make hormone therapy even more effective, certain targeted therapy drugs have been developed. These include:
- Afinitor: Afinitor (chemical name: everolimus) is an mTOR (mammalian target of rapamycin) inhibitor. Afinitor works against hormone-receptor-positive breast cancers that have stopped responding to aromatase inhibitors by stopping the cancer cells from getting the energy they need.
- Avastin: Avastin (chemical name: bevacizumab) works by blocking the growth of new blood vessels that cancer cells depend on to grow and function.
- Ibrance: Ibrance (chemical name: palbociclib) is a cyclin-dependent kinase 4/6 inhibitor. A kinase is a type of protein in the body that helps control cell division. Ibrance works by stopping cancer cells from dividing and growing.
- Kisqali: Kisqali (chemical name: ribociclib, formerly called LEE011) is also a cyclin-dependent kinase 4/6 inhibitor like Ibrance. A kinase is a type of protein in the body that helps control cell division. Kisqali works by stopping cancer cells from dividing and growing.
- Verzenio: Verzenio (chemical name: abemaciclib) is cyclin-dependent kinase 4/6 inhibitor, like Ibrance and Kisqali. A kinase is a type of protein in the body that helps control cell division. Verzenio works by stopping cancer cells from dividing and growing.
Targeted Therapy for Women with BRCA Gene Mutations
If you have hereditary breast cancer syndrome caused by inherited gene changes in BRCA1 and BRCA2, your cancer will be targeted with a type of drug known as a PARP inhibitor. The primary drug used is:
- Lynparza: Lynparza (chemical name: olaparib) is a PARP inhibitor. The PARP enzyme fixes DNA damage in both healthy cells and cancer cells. Lynparza works against metastatic HER2-negative breast cancer with a BRCA1 or BRCA2 mutation by making it very difficult for these cancer cells to fix DNA damage.
Rest assured, you are in good hands with Rocky Mountain Breast Specialists. We believe in treating the whole person, not just the disease, which is why we will work hard to create the best cancer treatment plan for you.
Breast Cancer Immunotherapy
Research has found that our own immune system can play an important role in fighting cancer. This resulted in a new category of cancer treatment called immunotherapy.
Breast cancer cells can disguise themselves as healthy cells so the checkpoints on the cells don’t work correctly to attack the cancer. When the immunotherapy drug blocks the production of these checkpoints, the body can recognize the cancer cells, allowing the immune system to do its job and attack the unhealthy cells.
Currently, the immunotherapy drugs approved for breast cancer are used for patients with triple-negative breast cancer and those with metastatic breast cancer whose biopsy shows that PD-L1 protein is part of the genetic make up of the cancer. Extensive breast cancer research is being done with patients in Colorado and across the United States to find new ways for immunotherapy to help more breast cancer patients.